Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model

• Published in: Osteoarthritis and cartilage Vol. 25; no. 6; pp. 964 - 975
• Main Authors: Iijima, Hirotaka, MSc, Ito, Akira, PhD, Nagai, Momoko, PhD, Tajino, Junichi, PhD, Yamaguchi, Shoki, MSc, Kiyan, Wataru, MSc, Nakahata, Akihiro, MSc, Zhang, Jue, Wang, Tianshu, Aoyama, Tomoki, MD, PhD, Nishitani, Kohei, MD, PhD, Kuroki, Hiroshi, PhD
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2017
• Subjects: Animals; Bone micro-CT; Bone morphogenetic protein; Bone Morphogenetic Protein 2 - drug effects; Bone Morphogenetic Protein 2 - metabolism; Bone Morphogenetic Protein 4 - drug effects; Bone Morphogenetic Protein 4 - metabolism; Bone Morphogenetic Protein 6 - drug effects; Bone Morphogenetic Protein 6 - metabolism; Bone Morphogenetic Protein Receptors, Type II - drug effects; Bone Morphogenetic Protein Receptors, Type II - metabolism; Bone Morphogenetic Proteins - drug effects; Bone Morphogenetic Proteins - metabolism; Cartilage; Cartilage, Articular - drug effects; Cartilage, Articular - metabolism; Chondrocytes - drug effects; Chondrocytes - metabolism; Cytokines; Exercise; Gremlin-1; Inhibitor of Differentiation Protein 1; Knee Joint - drug effects; Knee Joint - metabolism; Male; Osteoarthritis; Osteoarthritis, Knee - etiology; Osteoarthritis, Knee - metabolism; Physical Conditioning, Animal; Proteins - pharmacology; Rats; Rats, Wistar; Rheumatology; Smad5 Protein - drug effects; Smad5 Protein - metabolism; Tibial Meniscus Injuries - complications; Tibial Meniscus Injuries - metabolism; Weight-Bearing; Cartilage; Exercise; Bone morphogenetic protein; Gremlin-1; Bone micro-CT; Osteoarthritis

Summary Objective To evaluate the dose-response relationship of exercise loading in the cartilage-subchondral bone unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the knee. Design Destabilized medial meniscus (DMM) surgery was performed on the right knee of 12-week-old male Wistar...