Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells

• Published in: Microbes and Infection Vol. 3; no. 6; pp. 493 - 507
• Main Authors: O’Loughlin, Edward V, Robins-Browne, Roy M
• Format: Book Review Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01.05.2001; Amsterdam Elsevier; Paris
• Subjects: Bacteriology; Biological and medical sciences; Colitis - microbiology; Dysentery, Bacillary - microbiology; Escherichia coli; Fundamental and applied biological sciences. Psychology; haemolytic uremic syndrome; Hemolytic-Uremic Syndrome - microbiology; Humans; Microbiology; pathogenesis; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Shiga toxin; Shiga Toxin 1 - toxicity; Shiga Toxin 2 - toxicity; Shiga Toxins - pharmacology; Shiga Toxins - toxicity; Shigella dysenteriae; Shiga toxin; pathogenesis; haemolytic uremic syndrome; Kidney disease; Urinary system disease; Hemolytic uremic syndrome; Pathogenesis; Colibacillosis; Escherichia coli; Shigella dysenteriae; Hemopathy; Review; Shigellosis; Infection; Hemolytic anemia; Renal failure; Bacteriosis; Bacteria; Mechanism of action; Shiga like toxin; Enterobacteriaceae
• ISSN: 1286-4579; 1769-714X
• DOI: 10.1016/S1286-4579(01)01405-8

Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.