Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate

As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven flavonoids against URAT1, a renal transporter involved in urate re-uptake f...

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Published inNPJ science of food Vol. 4; no. 1; p. 3
Main Authors Toyoda, Yu, Takada, Tappei, Saito, Hiroki, Hirata, Hiroshi, Ota-Kontani, Ami, Kobayashi, Naoyuki, Tsuchiya, Youichi, Suzuki, Hiroshi
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 05.02.2020
Nature Publishing Group UK
Subjects
Brief Communication
Flavonoids
Food
Gout
Health risks
Hyperuricemia
Naringenin
Uric acid
Nutrition
Biochemistry
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Summary:As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases.
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ISSN:2396-8370
2396-8370
DOI:10.1038/s41538-020-0063-7