DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation

• Published in: iScience Vol. 23; no. 2; p. 100838
• Main Authors: MacKenzie, Douglas J., Robertson, Neil A., Rather, Iqbal, Reid, Claire, Sendzikaite, Gintare, Cruickshanks, Hazel, McBryan, Tony, Hodges, Andrew, Pritchard, Catrin, Blyth, Karen, Adams, Peter D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.02.2020; Elsevier
• Subjects: Biological Sciences; Cancer; Molecular Biology; Molecular Biology; Biological Sciences; Cancer

Approximately 10% of human colorectal cancer (CRC) are associated with activated BRAFV600E mutation, typically in absence of APC mutation and often associated with a CpG island methylator (CIMP) phenotype. To protect from cancer, normal intestinal epithelial cells respond to oncogenic BRAFV600E by a...