Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury

• Published in: Cell metabolism Vol. 31; no. 5; pp. 956 - 968.e5
• Main Authors: Saeedi, Bejan J., Liu, Ken H., Owens, Joshua A., Hunter-Chang, Sarah, Camacho, Mary C., Eboka, Richard U., Chandrasekharan, Bindu, Baker, Nusaiba F., Darby, Trevor M., Robinson, Brian S., Jones, Rheinallt M., Jones, Dean P., Neish, Andrew S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.05.2020
• Subjects: 5-methoxyindoleacetic acid; Animals; Drosophila; Gastrointestinal Microbiome; Hep G2 Cells; hepatotoxicity; Humans; Lacticaseibacillus rhamnosus - metabolism; Lactobacillus; Liver - injuries; Liver - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; microbiome; NF-E2-Related Factor 2 - deficiency; NF-E2-Related Factor 2 - metabolism; Nrf2; Oxidation-Reduction; Tumor Cells, Cultured; 5-methoxyindoleacetic acid; Nrf2; microbiome; hepatotoxicity; Lactobacillus

Many studies have suggested a role for gut-resident microbes (the “gut microbiome”) in modulating host health; however, the mechanisms by which they impact systemic physiology remain largely unknown. In this study, metabolomic and transcriptional profiling of germ-free and conventionalized mouse liv...