Catalytic Double Cyclization Process for Antitumor Agents against Breast Cancer Cell Lines

• Published in: iScience Vol. 3; pp. 279 - 288
• Main Authors: Mancuso, Raffaella, Ziccarelli, Ida, Chimento, Adele, Marino, Nadia, Della Ca’, Nicola, Sirianni, Rosa, Pezzi, Vincenzo, Gabriele, Bartolo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.05.2018; Elsevier
• Subjects: Drugs; Organic Synthesis; Toxicology Evaluation; Drugs; Toxicology Evaluation; Organic Synthesis

The development of efficient synthetic strategies for the discovery of novel antitumor molecules is a major goal in current research. In this context, we report here a catalytic double cyclization process leading to bicyclic heterocycles with significant antitumor activity on different human breast...