Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers

• Published in: iScience Vol. 26; no. 3; p. 106090
• Main Authors: Katsuta, Hiroki, Okuda, Satoru, Nagayama, Kazuaki, Machiyama, Hiroaki, Kidoaki, Satoru, Kato, Masashi, Sokabe, Masahiro, Miyata, Takaki, Hirata, Hiroaki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.03.2023; Elsevier
• Subjects: Biological sciences; Biophysics; Cell biology; Cell biology; Biological sciences; Biophysics

Contractile force generated in actomyosin stress fibers (SFs) is transmitted along SFs to the extracellular matrix (ECM), which contributes to cell migration and sensing of ECM rigidity. In this study, we show that efficient force transmission along SFs relies on actin crosslinking by α-actinin. Upo...