Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

• Published in: Cell metabolism Vol. 23; no. 6; pp. 1200 - 1206
• Main Authors: Chondronikola, Maria, Volpi, Elena, Børsheim, Elisabet, Porter, Craig, Saraf, Manish K., Annamalai, Palam, Yfanti, Christina, Chao, Tony, Wong, Daniel, Shinoda, Kosaku, Labbė, Sebastien M., Hurren, Nicholas M., Cesani, Fernardo, Kajimura, Shingo, Sidossis, Labros S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.06.2016
• Subjects: Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Cold Temperature; Humans; Insulin - pharmacology; Kinetics; Linear Models; Lipid Metabolism - drug effects; Lipids - blood; Lipoproteins - blood; Male; Middle Aged; Multivariate Analysis; Oxidation-Reduction - drug effects
• ISSN: 1550-4131; 1932-7420; 1932-7420
• DOI: 10.1016/j.cmet.2016.04.029

Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditio...