Discontinuation, suboptimal adherence, and reinitiation of oral HIV pre-exposure prophylaxis: a global systematic review and meta-analysis

• Published in: The lancet HIV Vol. 9; no. 4; p. e254
• Main Authors: Zhang, Jing, Li, Chunyan, Xu, Junjie, Hu, Zhili, Rutstein, Sarah E, Tucker, Joseph D, Ong, Jason J, Jiang, Yongjun, Geng, Wenqing, Wright, Sarah T, Cohen, Myron S, Shang, Hong, Tang, Weiming
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2022
• Subjects: Anti-HIV Agents - therapeutic use; Female; HIV Infections - drug therapy; HIV Infections - prevention & control; Homosexuality, Male; Humans; Male; Pre-Exposure Prophylaxis; Sexual and Gender Minorities

Poor adherence to oral HIV pre-exposure prophylaxis (PrEP) diminishes its clinical and public health benefits. This study synthesises evidence regarding discontinuation, adherence, and reinitiation of PrEP among geographically diverse PrEP users. We did a systematic review and meta-analysis evaluati...