Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD

• Published in: iScience Vol. 25; no. 1; p. 103626
• Main Authors: Stensland, Zachary C., Coleman, Brianne M., Rihanek, Marynette, Baxter, Ryan M., Gottlieb, Peter A., Hsieh, Elena W.Y., Sarapura, Virginia D., Simmons, Kimber M., Cambier, John C., Smith, Mia J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.01.2022; Elsevier
• Subjects: Cell biology; Immunological methods; Immunology; Cell biology; Immunological methods; Immunology

Autoimmune thyroid disease (AITD) is caused by aberrant activation of the immune system allowing autoreactive B and T cells to target the thyroid gland leading to disease. Although AITD is more frequently diagnosed in adults, children are also affected but rarely studied. Here, we performed phenotyp...