Flux Balance Analysis for Media Optimization and Genetic Targets to Improve Heterologous Siderophore Production

• Published in: iScience Vol. 23; no. 4; p. 101016
• Main Authors: Swayambhu, Girish, Moscatello, Nicholas, Atilla-Gokcumen, G. Ekin, Pfeifer, Blaine A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.04.2020; Elsevier
• Subjects: Biological Sciences; Biotechnology; Metabolic Engineering; Metabolic Engineering; Biological Sciences; Biotechnology

Siderophores are small molecule metal chelators secreted in sparse quantities by their native microbial hosts but can be engineered for enhanced production from heterologous hosts like Escherichia coli. These molecules have been proved to be capable of binding heavy metals of commercial and/or envir...