Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics

• Published in: Drug metabolism and pharmacokinetics Vol. 44; p. 100450
• Main Authors: Mukai, Hidefumi, Ogawa, Koki, Kato, Naoya, Kawakami, Shigeru
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2022; The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd
• Subjects: Base editing; COVID-19 - therapy; DNA barcode; Gene Editing; Humans; Ionizable lipid; Lipid nanoparticle; Lipids; Liposomes; mRNA; Nanoparticles; Nucleic acid; Positron emission tomography; Recombination; Review; RNA, Messenger - genetics; Targeting; Recombination; Targeting; DNA barcode; Gene editing; Base editing; mRNA; Ionizable lipid; Positron emission tomography; Lipid nanoparticle; Nucleic acid

Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease 2019 vaccines are perfect examples to highlight the role played by drug delivery systems in advancing human health. The fundament...