Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics

Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease 2019 vaccines are perfect examples to highlight the role played by drug delivery systems in advancing human health. The fundament...

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Published inDrug metabolism and pharmacokinetics Vol. 44; p. 100450
Main Authors Mukai, Hidefumi, Ogawa, Koki, Kato, Naoya, Kawakami, Shigeru
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2022
The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd
Subjects
Base editing
COVID-19 - therapy
DNA barcode
Gene Editing
Humans
Ionizable lipid
Lipid nanoparticle
Lipids
Liposomes
mRNA
Nanoparticles
Nucleic acid
Positron emission tomography
Recombination
Review
RNA, Messenger - genetics
Targeting
Recombination
Targeting
DNA barcode
Gene editing
Base editing
mRNA
Ionizable lipid
Positron emission tomography
Lipid nanoparticle
Nucleic acid
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Abstract Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease 2019 vaccines are perfect examples to highlight the role played by drug delivery systems in advancing human health. The fundamentals of LNPs for the delivery of nucleic acid- and mRNA-based therapeutics, are well established. Thus, future research on LNPs will focus on addressing the following: expanding the scope of drug delivery to different constituents of the human body, expanding the number of diseases that can be targeted, and studying the change in the pharmacokinetics of LNPs under physiological and pathological conditions. This review article provides an overview of recent advances aimed at expanding the application of LNPs, focusing on the pharmacokinetics and advantages of LNPs. In addition, analytical techniques, library construction and screening, rational design, active targeting, and applicability to gene editing therapy have also been discussed.
AbstractList Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease 2019 vaccines are perfect examples to highlight the role played by drug delivery systems in advancing human health. The fundamentals of LNPs for the delivery of nucleic acid- and mRNA-based therapeutics, are well established. Thus, future research on LNPs will focus on addressing the following: expanding the scope of drug delivery to different constituents of the human body, expanding the number of diseases that can be targeted, and studying the change in the pharmacokinetics of LNPs under physiological and pathological conditions. This review article provides an overview of recent advances aimed at expanding the application of LNPs, focusing on the pharmacokinetics and advantages of LNPs. In addition, analytical techniques, library construction and screening, rational design, active targeting, and applicability to gene editing therapy have also been discussed.Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease 2019 vaccines are perfect examples to highlight the role played by drug delivery systems in advancing human health. The fundamentals of LNPs for the delivery of nucleic acid- and mRNA-based therapeutics, are well established. Thus, future research on LNPs will focus on addressing the following: expanding the scope of drug delivery to different constituents of the human body, expanding the number of diseases that can be targeted, and studying the change in the pharmacokinetics of LNPs under physiological and pathological conditions. This review article provides an overview of recent advances aimed at expanding the application of LNPs, focusing on the pharmacokinetics and advantages of LNPs. In addition, analytical techniques, library construction and screening, rational design, active targeting, and applicability to gene editing therapy have also been discussed.
Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease 2019 vaccines are perfect examples to highlight the role played by drug delivery systems in advancing human health. The fundamentals of LNPs for the delivery of nucleic acid- and mRNA-based therapeutics, are well established. Thus, future research on LNPs will focus on addressing the following: expanding the scope of drug delivery to different constituents of the human body, expanding the number of diseases that can be targeted, and studying the change in the pharmacokinetics of LNPs under physiological and pathological conditions. This review article provides an overview of recent advances aimed at expanding the application of LNPs, focusing on the pharmacokinetics and advantages of LNPs. In addition, analytical techniques, library construction and screening, rational design, active targeting, and applicability to gene editing therapy have also been discussed.
ArticleNumber 100450
Author Kato, Naoya
Ogawa, Koki
Mukai, Hidefumi
Kawakami, Shigeru
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  surname: Ogawa
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  surname: Kawakami
  fullname: Kawakami, Shigeru
  email: skawakam@nagasaki-u.ac.jp
  organization: Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki-shi, Nagasaki, 852-8588, Japan
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ContentType Journal Article
Copyright 2022 The Japanese Society for the Study of Xenobiotics
Copyright © 2022 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
2022 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved. 2022 The Japanese Society for the Study of Xenobiotics
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Keywords Recombination
Targeting
DNA barcode
Gene editing
Base editing
mRNA
Ionizable lipid
Positron emission tomography
Lipid nanoparticle
Nucleic acid
Language English
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Snippet Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based...
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SubjectTerms Base editing
COVID-19 - therapy
DNA barcode
Gene Editing
Humans
Ionizable lipid
Lipid nanoparticle
Lipids
Liposomes
mRNA
Nanoparticles
Nucleic acid
Positron emission tomography
Recombination
Review
RNA, Messenger - genetics
Targeting
Title Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics
URI https://dx.doi.org/10.1016/j.dmpk.2022.100450
https://www.ncbi.nlm.nih.gov/pubmed/35381574
https://www.proquest.com/docview/2647654392
https://pubmed.ncbi.nlm.nih.gov/PMC9363157
Volume 44
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