Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells

• Published in: Oncology reports Vol. 40; no. 3; pp. 1752 - 1760
• Main Authors: Chen, Chin‑Fu, Yang, Jai‑Sing, Chen, Wen‑Kang, Lu, Chi‑Cheng, Chiang, Jo‑Hua, Chiu, Hong‑Yi, Tsai, Shih‑Chang, Juan, Yu‑Ning, Huang, Hao‑Jen, Way, Tzong‑Der
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.09.2018; Spandidos Publications UK Ltd
• Subjects: Acids; Agonists; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; bcl-Associated Death Protein - metabolism; Biomarkers, Tumor - metabolism; Cancer therapies; Carboxylic acids; Care and treatment; Caspases - metabolism; Cell death; Cell growth; Cell Proliferation - drug effects; Cell receptors; Chemotherapy; Cisplatin - pharmacology; Development and progression; Drug resistance; Drug Resistance, Neoplasm; Drug synergism; Genetic aspects; Head & neck cancer; Health aspects; Humans; Immunoglobulins; Laboratories; Leukemia; Medical prognosis; Membrane Potential, Mitochondrial - drug effects; Metastasis; Mouth cancer; Mouth Neoplasms - drug therapy; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Oral cancer; Penicillin; Phosphorylation; Phosphorylation - drug effects; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal transduction; Squamous cell carcinoma; Triterpenes - pharmacology; Tumor Cells, Cultured; Ursolic Acid; United States > US

Oral squamous cell carcinoma (OSCC) is a type of cancer with high morbidity and mortality rates worldwide; it also demonstrates chemotherapeutic resistance. Triterpenoid ursolic acid has been shown to exhibit various biological activities and anticancer effects in several preclinical studies. In our...