Exosomes as mediators of intercellular crosstalk in metabolism

• Published in: Cell metabolism Vol. 33; no. 9; pp. 1744 - 1762
• Main Authors: Isaac, Roi, Reis, Felipe Castellani Gomes, Ying, Wei, Olefsky, Jerrold M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.09.2021
• Subjects: Cell Communication; Exosomes - metabolism; Extracellular Vesicles - metabolism; Humans; Metabolic Diseases - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism

Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic...