Exosomes as mediators of intercellular crosstalk in metabolism

Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic...

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Published inCell metabolism Vol. 33; no. 9; pp. 1744 - 1762
Main Authors Isaac, Roi, Reis, Felipe Castellani Gomes, Ying, Wei, Olefsky, Jerrold M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 07.09.2021
Subjects
Cell Communication
Exosomes - metabolism
Extracellular Vesicles - metabolism
Humans
Metabolic Diseases - metabolism
MicroRNAs - genetics
MicroRNAs - metabolism
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Abstract Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic effects. Because of this, exosomes are important components of an intercellular and intraorgan communication system capable of carrying biologic signals from one cell type or tissue to another. The exosomal cargo consists of proteins, lipids, miRNAs, and other RNA species, and many of the biologic effects of exosomes have been attributed to miRNAs. Exosomal miRNAs have also been used as disease biomarkers. The field of exosome biology and metabolism is rapidly expanding, with new discoveries and reports appearing on a regular basis, and it is possible that potential therapeutic approaches for the use of exosomes or miRNAs in metabolic diseases will be initiated in the near future. Exosomes are intercellular and intraorgan communication components with similarities to a classical endocrine system. In this review, Isaac and Reis et al. discuss basic aspects of exosome biology and the role of exosomes in metabolic homeostasis including their potential use as therapeutic agents.
AbstractList Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic effects. Because of this, exosomes are important components of an intercellular and intraorgan communication system capable of carrying biologic signals from one cell type or tissue to another. The exosomal cargo consists of proteins, lipids, miRNAs, and other RNA species, and many of the biologic effects of exosomes have been attributed to miRNAs. Exosomal miRNAs have also been used as disease biomarkers. The field of exosome biology and metabolism is rapidly expanding, with new discoveries and reports appearing on a regular basis, and it is possible that potential therapeutic approaches for the use of exosomes or miRNAs in metabolic diseases will be initiated in the near future.Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic effects. Because of this, exosomes are important components of an intercellular and intraorgan communication system capable of carrying biologic signals from one cell type or tissue to another. The exosomal cargo consists of proteins, lipids, miRNAs, and other RNA species, and many of the biologic effects of exosomes have been attributed to miRNAs. Exosomal miRNAs have also been used as disease biomarkers. The field of exosome biology and metabolism is rapidly expanding, with new discoveries and reports appearing on a regular basis, and it is possible that potential therapeutic approaches for the use of exosomes or miRNAs in metabolic diseases will be initiated in the near future.
Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic effects. Because of this, exosomes are important components of an intercellular and intraorgan communication system capable of carrying biologic signals from one cell type or tissue to another. The exosomal cargo consists of proteins, lipids, miRNAs, and other RNA species, and many of the biologic effects of exosomes have been attributed to miRNAs. Exosomal miRNAs have also been used as disease biomarkers. The field of exosome biology and metabolism is rapidly expanding, with new discoveries and reports appearing on a regular basis, and it is possible that potential therapeutic approaches for the use of exosomes or miRNAs in metabolic diseases will be initiated in the near future. Exosomes are intercellular and intraorgan communication components with similarities to a classical endocrine system. In this review, Isaac and Reis et al. discuss basic aspects of exosome biology and the role of exosomes in metabolic homeostasis including their potential use as therapeutic agents.
Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic effects. Because of this, exosomes are important components of an intercellular and intraorgan communication system capable of carrying biologic signals from one cell type or tissue to another. The exosomal cargo consists of proteins, lipids, miRNAs, and other RNA species, and many of the biologic effects of exosomes have been attributed to miRNAs. Exosomal miRNAs have also been used as disease biomarkers. The field of exosome biology and metabolism is rapidly expanding, with new discoveries and reports appearing on a regular basis, and it is possible that potential therapeutic approaches for the use of exosomes or miRNAs in metabolic diseases will be initiated in the near future.
Author Olefsky, Jerrold M.
Ying, Wei
Isaac, Roi
Reis, Felipe Castellani Gomes
AuthorAffiliation 1 Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA
AuthorAffiliation_xml – name: 1 Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA
Author_xml – sequence: 1
  givenname: Roi
  surname: Isaac
  fullname: Isaac, Roi
  organization: Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA
– sequence: 2
  givenname: Felipe Castellani Gomes
  surname: Reis
  fullname: Reis, Felipe Castellani Gomes
  organization: Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA
– sequence: 3
  givenname: Wei
  surname: Ying
  fullname: Ying, Wei
  organization: Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA
– sequence: 4
  givenname: Jerrold M.
  surname: Olefsky
  fullname: Olefsky, Jerrold M.
  email: jolefsky@health.ucsd.edu
  organization: Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34496230$$D View this record in MEDLINE/PubMed
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Snippet Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once...
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SubjectTerms Cell Communication
Exosomes - metabolism
Extracellular Vesicles - metabolism
Humans
Metabolic Diseases - metabolism
MicroRNAs - genetics
MicroRNAs - metabolism
Title Exosomes as mediators of intercellular crosstalk in metabolism
URI https://dx.doi.org/10.1016/j.cmet.2021.08.006
https://www.ncbi.nlm.nih.gov/pubmed/34496230
https://www.proquest.com/docview/2571048375
https://pubmed.ncbi.nlm.nih.gov/PMC8428804
Volume 33
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