A tandem motif-based and structural approach can identify hidden functional phosphodiesterases

• Published in: Computational and structural biotechnology journal Vol. 19; pp. 970 - 975
• Main Authors: Kwiatkowski, Mateusz, Wong, Aloysius, Kozakiewicz, Anna, Gehring, Christoph, Jaworski, Krzysztof
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021; Research Network of Computational and Structural Biotechnology; Elsevier
• Subjects: AC-PDE activity; Adenylate cyclase (AC); AtKUP5; Calmodulin (CaM); Communications; Moonlighting protein; Phosphodiesterase (PDE); Phosphodiesterase (PDE); Moonlighting protein; AtKUP5; Adenylate cyclase (AC); AC-PDE activity; Calmodulin (CaM)

Cyclic nucleotide monophosphates (cNMPs) are increasingly recognized as essential signaling molecules governing many physiological and developmental processes in prokaryotes and eukaryotes. Degradation of cNMPs is as important as their generation because it offers the capability for transient and dy...