Inference of biochemical network models in S-system using multiobjective optimization approach

• Published in: Bioinformatics Vol. 24; no. 8; pp. 1085 - 1092
• Main Authors: Liu, Pang-Kai, Wang, Feng-Sheng
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.04.2008; Oxford Publishing Limited (England)
• Subjects: Algorithms; Bioinformatics; Biological and medical sciences; Computer Simulation; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling - methods; General aspects; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Models, Biological; Models, Statistical; Protein Interaction Mapping - methods; Proteome - metabolism; Signal Transduction - physiology; Software; Inference; Models; Bioinformatics; Optimization; Network

Motivation: The inference of biochemical networks, such as gene regulatory networks, protein–protein interaction networks, and metabolic pathway networks, from time-course data is one of the main challenges in systems biology. The ultimate goal of inferred modeling is to obtain expressions that quan...