Targeted vaccination and the speed of SARS-CoV-2 adaptation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 3
• Main Authors: Gandon, Sylvain, Lion, Sébastien
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 18.01.2022
• Subjects: Adaptation; Biodiversity; Biological Sciences; Coronaviruses; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - administration & dosage; Epidemiology; Humans; Immunization; Life Sciences; Models, Theoretical; Populations and Evolution; Santé publique et épidémiologie; SARS-CoV-2 - isolation & purification; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Vaccination - methods; Vaccines; Viral diseases; COVID-19; adaptation; SARS-CoV-2; evolutionary epidemiology; vaccination

The limited supply of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raises the question of targeted vaccination. Many countries have opted to vaccinate older and more sensitive hosts first to minimize the disease burden. However, what are the evolutionary consequences...