Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis

• Published in: Cell metabolism Vol. 34; no. 8; pp. 1201 - 1213.e5
• Main Authors: Gao, Hong, Jin, Zhongmou, Bandyopadhyay, Gautam, Wang, Gaowei, Zhang, Dinghong, Rocha, Karina Cunha e, Liu, Xiao, Zhao, Huayi, Kisseleva, Tatiana, Brenner, David A., Karin, Michael, Ying, Wei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.08.2022
• Subjects: Animals; Disease Models, Animal; extracellular vesicle; Fibrosis; hepatic stellate cell; Hepatic Stellate Cells - metabolism; hepatocyte; Hepatocytes - metabolism; iron; Iron - metabolism; Iron Overload - complications; Iron Overload - metabolism; Iron Overload - pathology; Kupffer Cells - metabolism; Lipogenesis; Liver - metabolism; Liver Cirrhosis - metabolism; liver fibrosis; liver steatosis; NAFLD; NASH; Non-alcoholic Fatty Liver Disease - metabolism; NAFLD; liver fibrosis; hepatocyte; iron; liver steatosis; hepatic stellate cell; NASH; extracellular vesicle

Hepatocytes have important roles in liver iron homeostasis, abnormalities in which are tightly associated with liver steatosis and fibrosis. Here, we show that non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are characterized by iron-deficient hepatocytes and iron overload in he...