PTOV1 promotes cisplatin-induced chemotherapy resistance by activating the nuclear factor kappa B pathway in ovarian cancer

• Published in: Molecular therapy. Oncolytics Vol. 20; pp. 499 - 507
• Main Authors: Shen, Hongwei, Liao, Bing, Wan, Zhiyong, Zhao, Yunhe, You, Zeshan, Liu, Jun, Lan, Jin, He, Shanyang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.03.2021; American Society of Gene & Cell Therapy; Elsevier
• Subjects: chemotherapy resistance; NF-κB pathway; Original; ovarian cancer; PTOV1; PTOV1; chemotherapy resistance; ovarian cancer; NF-κB pathway

Chemotherapy resistance is a bottleneck for ovarian cancer treatment; therefore, revealing its regulatory mechanism is critical. In the present study, we found that prostate tumor overexpressed-1 (PTOV1) was upregulated significantly in ovarian cancer cells and tissues. Patients with high PTOV1 leve...