New Azaphilones from Nigrospora oryzae Co-Cultured with Beauveria bassiana

In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the endophytes in the seeds of Dendrobium officinale, were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound 2...

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Published inMolecules (Basel, Switzerland) Vol. 23; no. 7; p. 1816
Main Authors Zhang, Zhuo-Xi, Yang, Xue-Qiong, Zhou, Qing-Yan, Wang, Bang-Yan, Hu, Ming, Yang, Ya-Bin, Zhou, Hao, Ding, Zhong-Tao
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.07.2018
MDPI
Subjects
antifungal selectivity
azaphilone
Beauveria bassiana
Carbon
co-culture
Conflicts of interest
Cotton
Experiments
Fungi
Hydrogenation
Metabolism
Metabolites
Natural products
Nigrospora oryzae
NO inhibitory activity
Spectrum analysis
China
Nigrospora oryzae
Beauveria bassiana
NO inhibitory activity
antifungal selectivity
azaphilone
co-culture
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Abstract In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the endophytes in the seeds of Dendrobium officinale, were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound 2 had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by N. oryzae against its co-culture fungus, B. bassiana, and common pathogens exhibited competitive interaction in this mix-culture. Compounds 1 and 2 showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 μM.
AbstractList In this study, the co-culture of and , the endophytes in the seeds of , were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by against its co-culture fungus, , and common pathogens exhibited competitive interaction in this mix-culture. Compounds and showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 μM.
In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana , the endophytes in the seeds of Dendrobium officinale , were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound 2 had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by N. oryzae against its co-culture fungus, B. bassiana , and common pathogens exhibited competitive interaction in this mix-culture. Compounds 1 and 2 showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 μM.
In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the endophytes in the seeds of Dendrobium officinale, were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound 2 had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by N. oryzae against its co-culture fungus, B. bassiana, and common pathogens exhibited competitive interaction in this mix-culture. Compounds 1 and 2 showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 μM.In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the endophytes in the seeds of Dendrobium officinale, were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound 2 had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by N. oryzae against its co-culture fungus, B. bassiana, and common pathogens exhibited competitive interaction in this mix-culture. Compounds 1 and 2 showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 μM.
In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the endophytes in the seeds of Dendrobium officinale, were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound 2 had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by N. oryzae against its co-culture fungus, B. bassiana, and common pathogens exhibited competitive interaction in this mix-culture. Compounds 1 and 2 showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 μM.
Author Zhou, Hao
Zhou, Qing-Yan
Wang, Bang-Yan
Ding, Zhong-Tao
Yang, Xue-Qiong
Hu, Ming
Zhang, Zhuo-Xi
Yang, Ya-Bin
AuthorAffiliation Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, 2st Cuihu North Road, Kunming 650091, China; 13278750367@163.com (Z.-X.Z.); yangxq@ynu.edu.cn (X.-Q.Y.); 13187884610@163.com (Q.-Y.Z.); gjk201113409218@163.com (B.-Y.W.); Hm1720553468@ynu.edu.cn (M.H.); zhouhaoa@163.com (H.Z.)
AuthorAffiliation_xml – name: Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, 2st Cuihu North Road, Kunming 650091, China; 13278750367@163.com (Z.-X.Z.); yangxq@ynu.edu.cn (X.-Q.Y.); 13187884610@163.com (Q.-Y.Z.); gjk201113409218@163.com (B.-Y.W.); Hm1720553468@ynu.edu.cn (M.H.); zhouhaoa@163.com (H.Z.)
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10.1002/med.21474
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Keywords Nigrospora oryzae
Beauveria bassiana
NO inhibitory activity
antifungal selectivity
azaphilone
co-culture
Language English
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Snippet In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the endophytes in the seeds of Dendrobium officinale, were examined for metabolite...
In this study, the co-culture of and , the endophytes in the seeds of , were examined for metabolite diversity. Five new azaphilones were isolated, and their...
In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana , the endophytes in the seeds of Dendrobium officinale , were examined for metabolite...
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SubjectTerms antifungal selectivity
azaphilone
Beauveria bassiana
Carbon
co-culture
Conflicts of interest
Cotton
Experiments
Fungi
Hydrogenation
Metabolism
Metabolites
Natural products
Nigrospora oryzae
NO inhibitory activity
Spectrum analysis
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Title New Azaphilones from Nigrospora oryzae Co-Cultured with Beauveria bassiana
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