Amphiphilic poly(l-amino acids) — New materials for drug delivery

• Published in: Journal of controlled release Vol. 161; no. 2; pp. 523 - 536
• Main Authors: Lalatsa, Aikaterini, Schätzlein, Andreas G., Mazza, Mariarosa, Le, Thi Bich Hang, Uchegbu, Ijeoma F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.07.2012
• Subjects: Acids; Amino acids; Amino Acids - administration & dosage; Amino Acids - chemistry; Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; composite polymers; Controlled release; Copolymers; Drug delivery; Drug Delivery Systems; drugs; Gene transfer; genes; Humans; hydrophilicity; Hydrophobicity; Micelles; nanofibers; nanoparticles; neoplasms; Peptide amphiphiles; Peptides - administration & dosage; Peptides - chemistry; Pharmacokinetics; Polymeric micelles; Polymeric vesicles; Polymers - administration & dosage; Polymers - chemistry; Self; Self-assembly; Solid polymeric nanoparticles; Vesicles; Solid polymeric nanoparticles; Self-assembly; Peptide amphiphiles; Polymeric vesicles; Polymeric micelles

The formulation of drug compounds into medicines will increasingly rely on the use of specially tailored molecules, which fundamentally alter the drug's pharmacokinetics to enable its therapeutic activity. This is particularly true of the more challenging hydrophobic drugs or therapeutic biolog...