The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes

• Published in: Cell metabolism Vol. 21; no. 3; pp. 369 - 378
• Main Authors: Seeley, Randy J., Chambers, Adam P., Sandoval, Darleen A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.03.2015
• Subjects: Adaptation, Physiological - physiology; Animals; Bariatric Surgery - methods; Body Weight - physiology; Diabetes Mellitus - physiopathology; Diabetes Mellitus - surgery; Food; Gastrointestinal Tract - physiology; Humans; Obesity - physiopathology; Obesity - surgery

Bariatric surgical procedures such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most potent treatments available to produce sustained reductions in body weight and improvements in glucose regulation. While traditionally these effects are attributed to mechanical a...