Effect of zinc on gene expression in osteoblastic MC3T3-E1 cells: enhancement of Runx2, OPG, and regucalcin mRNA expressions

• Published in: Molecular and cellular biochemistry Vol. 312; no. 1-2; pp. 157 - 166
• Main Authors: Yamaguchi, Masayoshi, Goto, Maya, Uchiyama, Satoshi, Nakagawa, Taeko
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.05.2008; Springer US; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Bones; Calcium-Binding Proteins - genetics; Cardiology; Cell Line; Cellular biology; Core Binding Factor Alpha 1 Subunit - genetics; Cycloheximide - pharmacology; Dichlororibofuranosylbenzimidazole - pharmacology; Gene expression; Gene Expression - drug effects; Intracellular Signaling Peptides and Proteins - genetics; Life Sciences; Medical Biochemistry; Mice; Oncology; Osteoblasts - drug effects; Osteoblasts - metabolism; Osteoprotegerin - genetics; Protein synthesis; Protein Synthesis Inhibitors - pharmacology; Ribonucleic acid; RNA; RNA, Messenger - metabolism; Sulfates; Up-Regulation - drug effects; Zinc; Zinc - pharmacology; Zinc Compounds - pharmacology; Osteoblast; Regucalcin; Bone formation; Zinc; OPG; Runx2

The effect of zinc sulfate on the mRNA expressions in Runx2, osteocalcin, α1(I) collagen, insulin-like growth factor-I (IGF-I), transforming growth factor-β1 (TGF-β1), osteoprotegerin (OPG), regucalcin, zinc transporter 1 (ZIP1), or glyceroaldehyde-3-phosphate dehydrogenase (G3PDH) in osteoblastic M...