Adenovirus vector-based vaccine for infectious diseases

• Published in: Drug metabolism and pharmacokinetics Vol. 42; p. 100432
• Main Authors: Sakurai, Fuminori, Tachibana, Masashi, Mizuguchi, Hiroyuki
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2022; The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd
• Subjects: Adenoviridae - genetics; Adenovirus Vaccines; Adenovirus vector; Communicable Diseases; COVID-19; Genetic Vectors - genetics; Humans; Infectious diseases; Innate immunity; Pre-existing antibody; Review; SARS-CoV-2; Vaccine; Vaccines; COVID-19; Innate immunity; Vaccine; Infectious diseases; Adenovirus vector; Pre-existing antibody

Replication-incompetent adenovirus (Ad) vectors have been widely used as gene delivery vehicles in both gene therapy studies and basic studies for gene function analysis due to their highly advantageous properties, which include high transduction efficiencies, relatively large capacities for transge...