The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells

• Published in: Cell metabolism Vol. 33; no. 2; pp. 242 - 257
• Main Authors: Trivedi, Parth, Wang, Shuang, Friedman, Scott L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.02.2021
• Subjects: Animals; Cell Plasticity; Hepatic Stellate Cells - metabolism; Humans

Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity enables them to regulate a remarkable range of physiologic and pathologic responses. To support their functions in health and disease, HSCs engage pathways regulating carbohydrate, mitochondrial, lipid, and r...