Translational Control via Protein-Regulated Upstream Open Reading Frames

• Published in: Cell Vol. 145; no. 6; pp. 902 - 913
• Main Authors: Medenbach, Jan, Seiler, Markus, Hentze, Matthias W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.06.2011
• Subjects: 5' Untranslated Regions; adverse effects; Animals; Binding Sites; DNA-Binding Proteins - genetics; Drosophila; Drosophila - genetics; Drosophila - metabolism; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Female; Gene Expression Regulation; Male; messenger RNA; Nuclear Proteins - genetics; Open Reading Frames; Peptide Chain Initiation, Translational; Protein Biosynthesis; protein synthesis; ribosomes; Ribosomes - metabolism; RNA-binding proteins; RNA-Binding Proteins - metabolism; Transcription Factors - genetics; translation (genetics)

Analysis of the regulation of msl-2 mRNA by Sex lethal (SXL), which is critical for dosage compensation in Drosophila, has uncovered a mode of translational control based on common 5′ untranslated region elements, upstream open reading frames (uORFs), and interaction sites for RNA-binding proteins....