Osteogenic and antimicrobial nanoparticulate calcium phosphate and poly-(d,l-lactide-co-glycolide) powders for the treatment of osteomyelitis

• Published in: Materials Science & Engineering C Vol. 33; no. 6; pp. 3362 - 3373
• Main Authors: Uskoković, Vuk, Hoover, Charles, Vukomanović, Marija, Uskoković, Dragan P., Desai, Tejal A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2013
• Subjects: Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Antibiotics; Bacteria; Biocompatibility; Biomedical materials; Calcium phosphate; Calcium Phosphates - chemistry; Cell Line; Clindamycin - chemistry; Clindamycin - pharmacology; Clindamycin - therapeutic use; Collagen Type I - metabolism; Controlled drug delivery; Core Binding Factor Alpha 1 Subunit - metabolism; Hydrogen-Ion Concentration; Lactic Acid - chemistry; Mice; Nanocomposites; Nanomaterials; Nanoparticles - chemistry; Nanostructure; Osteoblasts - cytology; Osteoblasts - metabolism; Osteocalcin - metabolism; Osteogenesis; Osteogenesis - drug effects; Osteomyelitis; Osteomyelitis - drug therapy; Osteopontin - metabolism; Poly-lactide-co-glycolide; Polyglycolic Acid - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Staphylococcus aureus; Staphylococcus aureus - drug effects; Osteomyelitis; Calcium phosphate; Controlled drug delivery; Poly-lactide-co-glycolide; Osteogenesis; Staphylococcus aureus

Development of a material for simultaneous sustained and localized delivery of antibiotics and induction of spontaneous regeneration of hard tissues affected by osteomyelitis stands for an important clinical need. In this work, a comparative analysis of the bacterial and osteoblastic cell response t...