A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets

• Published in: Cell host & microbe Vol. 22; no. 5; pp. 615 - 626.e8
• Main Authors: Imai, Masaki, Watanabe, Tokiko, Kiso, Maki, Nakajima, Noriko, Yamayoshi, Seiya, Iwatsuki-Horimoto, Kiyoko, Hatta, Masato, Yamada, Shinya, Ito, Mutsumi, Sakai-Tagawa, Yuko, Shirakura, Masayuki, Takashita, Emi, Fujisaki, Seiichiro, McBride, Ryan, Thompson, Andrew J., Takahashi, Kenta, Maemura, Tadashi, Mitake, Hiromichi, Chiba, Shiho, Zhong, Gongxun, Fan, Shufang, Oishi, Kohei, Yasuhara, Atsuhiro, Takada, Kosuke, Nakao, Tomomi, Fukuyama, Satoshi, Yamashita, Makoto, Lopes, Tiago J.S., Neumann, Gabriele, Odagiri, Takato, Watanabe, Shinji, Shu, Yuelong, Paulson, James C., Hasegawa, Hideki, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.11.2017
• Subjects: Animals; Antiviral Agents - pharmacology; antiviral sensitivity; Brain - pathology; Brain - virology; Cell Line; Chickens - virology; Conjunctiva - pathology; Conjunctiva - virology; Disease Models, Animal; Enzyme Inhibitors - pharmacology; ferrets; Ferrets - virology; highly pathogenic avian influenza H7N9 viruses; Humans; Influenza A Virus, H7N9 Subtype - isolation & purification; Influenza A Virus, H7N9 Subtype - pathogenicity; Influenza in Birds - virology; Lung - pathology; Lung - virology; Macaca - virology; Mice; Neuraminidase - drug effects; nonhuman primates; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; pathogenicity; receptor-binding specificity; replication capacity; Respiratory Tract Infections - pathology; Respiratory Tract Infections - virology; transmissibility; Virus Replication; antiviral sensitivity; pathogenicity; receptor-binding specificity; ferrets; transmissibility; replication capacity; nonhuman primates; highly pathogenic avian influenza H7N9 viruses; mice

Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants...