Optimizing peptide nucleic acid-based pretargeting for enhanced targeted radionuclide therapy

• Published in: Journal of controlled release Vol. 381; p. 113551
• Main Authors: Altai, Mohamed, Nagy, Ábel, Granit, Pauline, Zedan, Wahed, Cerezo-Magaña, Myriam, Park, Julie, Lückerath, Katharina, Geres, Susanne, Sydoff, Marie, Thorek, Daniel L.J., Westerlund, Kristina, Ulmert, David, Karlström, Amelie Eriksson
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.05.2025
• Subjects: Animals; Antibody; Antineoplastic Agents, Immunological - administration & dosage; Antineoplastic Agents, Immunological - pharmacokinetics; Antineoplastic Agents, Immunological - therapeutic use; blood circulation; Breast Neoplasms - radiotherapy; Cancer and Oncology; Cancer och onkologi; Cell Line, Tumor; Clinical Medicine; crosslinking; disease progression; dyes; erbB-2 receptor; Female; flow cytometry; half life; Humans; Klinisk medicin; Lutetium - administration & dosage; Lutetium - pharmacokinetics; Lutetium - therapeutic use; Medical and Health Sciences; Medicin och hälsovetenskap; Mice; Mice, Nude; neoplasms; Neoplasms - radiotherapy; nucleic acids; Peptide nucleic acid; Peptide Nucleic Acids - administration & dosage; Peptide Nucleic Acids - chemistry; Peptide Nucleic Acids - pharmacokinetics; peptides; Pretargeting; Radioisotopes - administration & dosage; Radioisotopes - therapeutic use; radiolabeling; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - pharmacokinetics; Radiopharmaceuticals - therapeutic use; Radiotherapy; Receptor, ErbB-2 - metabolism; Site-specific labeling; therapeutics; Trastuzumab - administration & dosage; Trastuzumab - chemistry; Trastuzumab - pharmacokinetics; Trastuzumab - therapeutic use; ultraviolet radiation; Peptide nucleic acid; Radiotherapy; Antibody; Pretargeting; Site-specific labeling

Radiolabeled targeting agents have emerged as valuable tools for the treatment of disseminated cancer. Monoclonal antibodies (mAbs) are widely employed as carriers for diagnostic and therapeutic radionuclides due to their exceptional specificity and affinity. However, their prolonged circulatory hal...