Optimizing peptide nucleic acid-based pretargeting for enhanced targeted radionuclide therapy - Altai, Mohamed; Nagy, Ábel; Granit, Pauline; Zedan, Wahed; Cerezo-Magaña, Myriam; Park, Julie; Lückerath, Katharina; Geres, Susanne; Sydoff, Marie; Thorek, Daniel L.J.; Westerlund, Kristina; Ulmert, David; et al. (Journal of controlled release, 2025)
Keywords: Animals; Antibody; Antineoplastic Agents, Immunological - administration & dosage; Antineoplastic Agents, Immunological - pharmacokinetics; Antineoplastic Agents, Immunological - therapeutic use; blood circulation; Breast Neoplasms - radiotherapy; Cancer and Oncology; Cancer och onkologi; Cell Line, Tumor; Clinical Medicine; crosslinking; disease progression; dyes; erbB-2 receptor; Female; flow cytometry; half life; Humans; Klinisk medicin; Lutetium - administration & dosage; Lutetium - pharmacokinetics; Lutetium - therapeutic use; Medical and Health Sciences; Medicin och hälsovetenskap; Mice; Mice, Nude; neoplasms; Neoplasms - radiotherapy; nucleic acids; Peptide nucleic acid; Peptide Nucleic Acids - administration & dosage; Peptide Nucleic Acids - chemistry; Peptide Nucleic Acids - pharmacokinetics; peptides; Pretargeting; Radioisotopes - administration & dosage; Radioisotopes - therapeutic use; radiolabeling; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - pharmacokinetics; Radiopharmaceuticals - therapeutic use; Radiotherapy; Receptor, ErbB-2 - metabolism; Site-specific labeling; therapeutics; Trastuzumab - administration & dosage; Trastuzumab - chemistry; Trastuzumab - pharmacokinetics; Trastuzumab - therapeutic use; ultraviolet radiation; Peptide nucleic acid; Radiotherapy; Antibody; Pretargeting; Site-specific labeling