Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing

• Published in: Nucleic acids research Vol. 44; no. 9; pp. 4014 - 4024
• Main Authors: Chandran, Anandhakumar, Syed, Junetha, Taylor, Rhys D, Kashiwazaki, Gengo, Sato, Shinsuke, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 19.05.2016
• Subjects: Alkylating Agents - chemistry; Alkylation; Base Sequence; Chemical Biology and Nucleic Acid Chemistry; DNA - chemistry; Genome, Human - genetics; High-Throughput Nucleotide Sequencing; Humans; Imidazoles - chemistry; Nylons - chemistry; Promoter Regions, Genetic - genetics; Pyrroles - chemistry; Receptor, ErbB-2 - genetics

Chemically engineered small molecules targeting specific genomic sequences play an important role in drug development research. Pyrrole-imidazole polyamides (PIPs) are a group of molecules that can bind to the DNA minor-groove and can be engineered to target specific sequences. Their biological effe...