Effect of vitamin E supplementation on antioxidant defense systems and humoral immune responses in young, middle-aged and elderly Korean women
Summary Free radical-mediated oxidative stress has been implicated in the pathogenesis of numerous chronic diseases. Vitamin E is known to play an important role in the free-radical quenching process. However, clinical trials with vitamin E have yielded contrasting results in the prevention of sever...
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| Published in | Journal of Nutritional Science and Vitaminology Vol. 49; no. 2; pp. 94 - 99 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
Center for Academic Publications Japan
01.04.2003
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-4800 1881-7742 |
| DOI | 10.3177/jnsv.49.94 |
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| Abstract | Summary Free radical-mediated oxidative stress has been implicated in the pathogenesis of numerous chronic diseases. Vitamin E is known to play an important role in the free-radical quenching process. However, clinical trials with vitamin E have yielded contrasting results in the prevention of several diseases related to oxidative stress. This study was undertaken to investigate the antioxidative and humoral immunologic effects of vitamin E supplementation in three different age groups: young (mean age 32.7 =+- 5.7y), middle-aged (mean age 47.0 =+- 5.0y) and elderly (67.6 =+- 4.7y) women. Volunteer subjects were given a supplement of 400 IU dl-a-tocopherol acetate for 6 wk. Thiobarbituric acid reacting substances (TBARS) in the plasma significantly decreased with vitamin E supplementation. In addition, the radical scavenger activities (RSA) of red blood cells significantly increased with vitamin E supplementation in all age groups. However, humoral immune response modulation was not observed following vitamin E supplementation. Even though there is no clear indication that vitamin E supplementation is necessary to improve the humoral immune functions, vitamin E supplementation may be beneficial to all adult age groups as a preventive measure for complications related to oxidative damage. |
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| AbstractList | Free radical-mediated oxidative stress has been implicated in the pathogenesis of numerous chronic diseases. Vitamin E is known to play an important role in the free-radical quenching process. However, clinical trials with vitamin E have yielded contrasting results in the prevention of several diseases related to oxidative stress. This study was undertaken to investigate the antioxidative and humoral immunologic effects of vitamin E supplementation in three different age groups: young (mean age 32.7±5.7 y), middle-aged (mean age 47.0±5.0 y) and elderly (67.6±4.7 y) women. Volunteer subjects were given a supplement of 400 IU dl-α-tocopherol acetate for 6 wk. Thiobarbituric acid reacting substances (TBARS) in the plasma significantly decreased with vitamin E supplementation. In addition, the radical scavenger activities (RSA) of red blood cells significantly increased with vitamin E supplementation in all age groups. However, humoral immune response modulation was not observed following vitamin E supplementation. Even though there is no clear indication that vitamin E supplementation is necessary to improve the humoral immune functions, vitamin E supplementation may be beneficial to all adult age groups as a preventive measure for complications related to oxidative damage. Summary Free radical-mediated oxidative stress has been implicated in the pathogenesis of numerous chronic diseases. Vitamin E is known to play an important role in the free-radical quenching process. However, clinical trials with vitamin E have yielded contrasting results in the prevention of several diseases related to oxidative stress. This study was undertaken to investigate the antioxidative and humoral immunologic effects of vitamin E supplementation in three different age groups: young (mean age 32.7 =+- 5.7y), middle-aged (mean age 47.0 =+- 5.0y) and elderly (67.6 =+- 4.7y) women. Volunteer subjects were given a supplement of 400 IU dl-a-tocopherol acetate for 6 wk. Thiobarbituric acid reacting substances (TBARS) in the plasma significantly decreased with vitamin E supplementation. In addition, the radical scavenger activities (RSA) of red blood cells significantly increased with vitamin E supplementation in all age groups. However, humoral immune response modulation was not observed following vitamin E supplementation. Even though there is no clear indication that vitamin E supplementation is necessary to improve the humoral immune functions, vitamin E supplementation may be beneficial to all adult age groups as a preventive measure for complications related to oxidative damage. Free radical-mediated oxidative stress has been implicated in the pathogenesis of numerous chronic diseases. Vitamin E is known to play an important role in the free-radical quenching process. However, clinical trials with vitamin E have yielded contrasting results in the prevention of several diseases related to oxidative stress. This study was undertaken to investigate the antioxidative and humoral immunologic effects of vitamin E supplementation in three different age groups: young (mean age 32.7 +/- 5.7 y), middle-aged (mean age 47.0 +/- 5.0 y) and elderly (67.6 +/- 4.7 y) women. Volunteer subjects were given a supplement of 400 IU dl-alpha-tocopherol acetate for 6 wk. Thiobarbituric acid reacting substances (TBARS) in the plasma significantly decreased with vitamin E supplementation. In addition, the radical scavenger activities (RSA) of red blood cells significantly increased with vitamin E supplementation in all age groups. However, humoral immune response modulation was not observed following vitamin E supplementation. Even though there is no clear indication that vitamin E supplementation is necessary to improve the humoral immune functions, vitamin E supplementation may be beneficial to all adult age groups as a preventive measure for complications related to oxidative damage.Free radical-mediated oxidative stress has been implicated in the pathogenesis of numerous chronic diseases. Vitamin E is known to play an important role in the free-radical quenching process. However, clinical trials with vitamin E have yielded contrasting results in the prevention of several diseases related to oxidative stress. This study was undertaken to investigate the antioxidative and humoral immunologic effects of vitamin E supplementation in three different age groups: young (mean age 32.7 +/- 5.7 y), middle-aged (mean age 47.0 +/- 5.0 y) and elderly (67.6 +/- 4.7 y) women. Volunteer subjects were given a supplement of 400 IU dl-alpha-tocopherol acetate for 6 wk. Thiobarbituric acid reacting substances (TBARS) in the plasma significantly decreased with vitamin E supplementation. In addition, the radical scavenger activities (RSA) of red blood cells significantly increased with vitamin E supplementation in all age groups. However, humoral immune response modulation was not observed following vitamin E supplementation. Even though there is no clear indication that vitamin E supplementation is necessary to improve the humoral immune functions, vitamin E supplementation may be beneficial to all adult age groups as a preventive measure for complications related to oxidative damage. Free radical-mediated oxidative stress has been implicated in the pathogenesis of numerous chronic diseases. Vitamin E is known to play an important role in the free-radical quenching process. However, clinical trials with vitamin E have yielded contrasting results in the prevention of several diseases related to oxidative stress. This study was undertaken to investigate the antioxidative and humoral immunologic effects of vitamin E supplementation in three different age groups: young (mean age 32.7 +/- 5.7 y), middle-aged (mean age 47.0 +/- 5.0 y) and elderly (67.6 +/- 4.7 y) women. Volunteer subjects were given a supplement of 400 IU dl-alpha-tocopherol acetate for 6 wk. Thiobarbituric acid reacting substances (TBARS) in the plasma significantly decreased with vitamin E supplementation. In addition, the radical scavenger activities (RSA) of red blood cells significantly increased with vitamin E supplementation in all age groups. However, humoral immune response modulation was not observed following vitamin E supplementation. Even though there is no clear indication that vitamin E supplementation is necessary to improve the humoral immune functions, vitamin E supplementation may be beneficial to all adult age groups as a preventive measure for complications related to oxidative damage. |
| Author | Kim, Y.J Park, O.J. (Hannam Univ., Daejeon (Korea R.)) Kim, S.H Kim, W.K Kim, H.Y.P |
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| References | 28) Meydani SN, Barklund MP, Liu S. 1990. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 52: 557-563. 10) Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ, Brown MJ. 1999. Randomized controlled trial of vitamin E in patients with coronary disease. Cambridge Heart Antioxidant study (CHAOS). Lancet 347: 781-786. 25) Gey KF, Puska P, Jordon P, Moser UK. 1991. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr 53: 326S-334S. 21) Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70 (1): 158-169. 14) Heinonen OP, Albanes D, Virtamo J, Taylor PR, Huttunen JK, Hartman AM, Haapakoski J, Malila N, Rautalahti M, Ripatti S, Maenpaa H, Teerenhovi L, Koss L, Virolainen M, Edwards BK. 1998. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst 90: 440-446. 2) Jacob RA, Burri BJ. 1996. Oxidative damage and defense. Am J Clin Nutr 63: 985S-990S. 1) Oberley LM. 1988. Free radicals and diabetes. Free Radic Biol Med 5: 113-124. 3) Lyons TJ. 1991. Oxidized low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes? Diabetic Med 8: 411-419. 27) De Waart FG, Portengen L, Doekes G, Verwaal CJ, Kok FJ.1997. Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects. Br J Nutr 78: 761-774. 31) Buzina-Suboticanec K, Buzina R, Stavljenic A, Farley TMM, Haller J, Bergman-Markovic B, Gorajscan M. 1998. Ageing, nutritional status and immune response. Int J Vit Nutr Res 68: 133-141. 6) Burton GW, Traber MG. 1990. Vitamin E: antioxidant activity, biokinetics and bioavailability. Ann Rev Nutr 10: 357-382. 22) Johansson LH, Borg LA. 1988. A spectrophotometric method for determination of catalase activity in small tissue samples. Anal Biochem 174: 331-336. 24) Lee C-Y J, Wan JM-F. 2000. Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian men and women. J Nutr 130: 2932-2937. 23) Sternberg JC. 1985. A rate nephlometer for measuring specific proteins by immunoprecipitate reaction. Clin Chem 23: 1456-1464. 30) De la Fuente M, Ferrandez MD, Burgos MS, Soler A, Prieto A, Miquel J. 1998. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 76: 373-380. 5) Chow CK. 1991. Vitamin E and oxidative stress. Free Radical Biol Med 11: 215-232. 11) White E, Shannon JS, Patterson RE. 1997. Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidemiol Biomarkers Prev 6: 769-774. 15) Hartman TJ, Albanes D, Pietinen P, Levi F, Pasche C, Lucchini F, La Vecchia C. 2001. Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer 91: 260-263. 18) Motchnik PA, Frei B, Ames BN. 1994. Measurement of antioxidants in human blood plasma. Method Erczymol 234: 269-279 12) Albanes D, Malila N, Taylor PR, Huttunen JK, Virtamo J, Edwards BK, Rautalahti M, Hartman AM, Virtanen OP, Heinpnen OP. 2000. Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland). Cancer Causes Control 11: 197-205. 13) Hartman TJ, Albanes D, Pietinen P, Hartman AM, Rautalahti M, Tangrea JA, Taylor PR. 1998. The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev 4: 335-340. 29) Moriguchi S, Muraga M. 2000. Vitamin E and immunity. Vit Hor 59: 305-336. 17) Zielanski S, Wartanowicz M, Klose A. 1986. The effect of ascorbic acid and alpha-tocopherol supplementation on serum proteins and immunoglobulin concentration in the elderly. Nutr Int 2: 1-5. 4) Babiy AV, Gebicki JM, Sullivan DR, Willey K. 1992. Increased oxidizability of plasma lipoproteins in diabetic patients can be decreased by probucol therapy and is not due to glycation. Biochem Pharmacol 43: 995-1000. 9) Kushi LH, Folson AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM. 1996. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Eng J Med 334: 1156-1162. 16) Goodwin JS, Garry TJ. 1983. Relationship between megadoses vitamin supplementation and immunological function in a healthy elderly population. Clin Exp Immunol 51: 647-653. 7) Kaul N, Devaraj S, Jialal I. 2001. Alpha-tocopherol and atherosclerosis. Exp Biol Med (Maywood) 226: 5-12. 20) Regnault C. 1993. Influence of beta-carotene, vitamin E and vitamin C on endogenous antioxidant defenses in erythrocytes. Ann Pharmacol 27: 1349-1350. 8) Rimm E, Stampfer MJ, Ascherio A, Giovannucci E, Golditz GA, Willett WC. 1993 . Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 328: 1450-1456. 19) Yagi K. 1982. Lipid Peroxidation in Biology and Medicine, Vol 223. Lowenstein Press, NY. 26) Newzil J, Weber C, Kontush A. 2000. The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease. Atherosclerosis 157: 257-283. |
| References_xml | – reference: 2) Jacob RA, Burri BJ. 1996. Oxidative damage and defense. Am J Clin Nutr 63: 985S-990S. – reference: 27) De Waart FG, Portengen L, Doekes G, Verwaal CJ, Kok FJ.1997. Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects. Br J Nutr 78: 761-774. – reference: 11) White E, Shannon JS, Patterson RE. 1997. Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidemiol Biomarkers Prev 6: 769-774. – reference: 12) Albanes D, Malila N, Taylor PR, Huttunen JK, Virtamo J, Edwards BK, Rautalahti M, Hartman AM, Virtanen OP, Heinpnen OP. 2000. Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland). Cancer Causes Control 11: 197-205. – reference: 13) Hartman TJ, Albanes D, Pietinen P, Hartman AM, Rautalahti M, Tangrea JA, Taylor PR. 1998. The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev 4: 335-340. – reference: 6) Burton GW, Traber MG. 1990. Vitamin E: antioxidant activity, biokinetics and bioavailability. Ann Rev Nutr 10: 357-382. – reference: 15) Hartman TJ, Albanes D, Pietinen P, Levi F, Pasche C, Lucchini F, La Vecchia C. 2001. Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer 91: 260-263. – reference: 19) Yagi K. 1982. Lipid Peroxidation in Biology and Medicine, Vol 223. Lowenstein Press, NY. – reference: 20) Regnault C. 1993. Influence of beta-carotene, vitamin E and vitamin C on endogenous antioxidant defenses in erythrocytes. Ann Pharmacol 27: 1349-1350. – reference: 28) Meydani SN, Barklund MP, Liu S. 1990. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 52: 557-563. – reference: 24) Lee C-Y J, Wan JM-F. 2000. Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian men and women. J Nutr 130: 2932-2937. – reference: 9) Kushi LH, Folson AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM. 1996. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Eng J Med 334: 1156-1162. – reference: 17) Zielanski S, Wartanowicz M, Klose A. 1986. The effect of ascorbic acid and alpha-tocopherol supplementation on serum proteins and immunoglobulin concentration in the elderly. Nutr Int 2: 1-5. – reference: 8) Rimm E, Stampfer MJ, Ascherio A, Giovannucci E, Golditz GA, Willett WC. 1993 . Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 328: 1450-1456. – reference: 1) Oberley LM. 1988. Free radicals and diabetes. Free Radic Biol Med 5: 113-124. – reference: 5) Chow CK. 1991. Vitamin E and oxidative stress. Free Radical Biol Med 11: 215-232. – reference: 16) Goodwin JS, Garry TJ. 1983. Relationship between megadoses vitamin supplementation and immunological function in a healthy elderly population. Clin Exp Immunol 51: 647-653. – reference: 18) Motchnik PA, Frei B, Ames BN. 1994. Measurement of antioxidants in human blood plasma. Method Erczymol 234: 269-279 – reference: 3) Lyons TJ. 1991. Oxidized low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes? Diabetic Med 8: 411-419. – reference: 10) Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ, Brown MJ. 1999. Randomized controlled trial of vitamin E in patients with coronary disease. Cambridge Heart Antioxidant study (CHAOS). Lancet 347: 781-786. – reference: 30) De la Fuente M, Ferrandez MD, Burgos MS, Soler A, Prieto A, Miquel J. 1998. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 76: 373-380. – reference: 14) Heinonen OP, Albanes D, Virtamo J, Taylor PR, Huttunen JK, Hartman AM, Haapakoski J, Malila N, Rautalahti M, Ripatti S, Maenpaa H, Teerenhovi L, Koss L, Virolainen M, Edwards BK. 1998. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst 90: 440-446. – reference: 23) Sternberg JC. 1985. A rate nephlometer for measuring specific proteins by immunoprecipitate reaction. Clin Chem 23: 1456-1464. – reference: 26) Newzil J, Weber C, Kontush A. 2000. The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease. Atherosclerosis 157: 257-283. – reference: 4) Babiy AV, Gebicki JM, Sullivan DR, Willey K. 1992. Increased oxidizability of plasma lipoproteins in diabetic patients can be decreased by probucol therapy and is not due to glycation. Biochem Pharmacol 43: 995-1000. – reference: 31) Buzina-Suboticanec K, Buzina R, Stavljenic A, Farley TMM, Haller J, Bergman-Markovic B, Gorajscan M. 1998. Ageing, nutritional status and immune response. Int J Vit Nutr Res 68: 133-141. – reference: 25) Gey KF, Puska P, Jordon P, Moser UK. 1991. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr 53: 326S-334S. – reference: 21) Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70 (1): 158-169. – reference: 29) Moriguchi S, Muraga M. 2000. Vitamin E and immunity. Vit Hor 59: 305-336. – reference: 22) Johansson LH, Borg LA. 1988. A spectrophotometric method for determination of catalase activity in small tissue samples. Anal Biochem 174: 331-336. – reference: 7) Kaul N, Devaraj S, Jialal I. 2001. Alpha-tocopherol and atherosclerosis. Exp Biol Med (Maywood) 226: 5-12. |
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| SubjectTerms | Adult ADULTS Aged Aging - blood Aging - drug effects Aging - immunology Analysis of Variance Antibody Formation - drug effects antioxidant defense ANTIOXIDANTS Antioxidants - pharmacology Biological and medical sciences Diet Dietary Supplements - statistics & numerical data ELDERLY Female Fundamental and applied biological sciences. Psychology Humans humoral immune response HUMORAL IMMUNITY IMMUNE RESPONSE Immunoglobulins - blood Immunoglobulins - drug effects Korea KOREA REPUBLIC Middle Aged Nutrition Policy Oxidative Stress - drug effects Oxidoreductases - blood Oxidoreductases - immunology radical scavenger activity SUPPLEMENTS Thiobarbituric Acid Reactive Substances - metabolism VITAMIN E Vitamin E - blood Vitamin E - immunology Vitamin E - pharmacology WOMEN YOUTH |
| Title | Effect of vitamin E supplementation on antioxidant defense systems and humoral immune responses in young, middle-aged and elderly Korean women |
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