Metabolic modeling of single bronchoalveolar macrophages reveals regulators of hyperinflammation in COVID-19

• Published in: iScience Vol. 25; no. 11; p. 105319
• Main Authors: Zhao, Qiuchen, Yu, Zhenyang, Zhang, Shengyuan, Shen, Xu-Rui, Yang, Hao, Xu, Yangyang, Liu, Yang, Yang, Lin, Zhang, Qing, Chen, Jiaqi, Lu, Mengmeng, Luo, Fei, Hu, Mingming, Gong, Yan, Xie, Conghua, Zhou, Peng, Wang, Li, Su, Lishan, Zhang, Zheng, Cheng, Liang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.11.2022; Elsevier
• Subjects: Bioinformatics; Biological sciences; Immunology; Virology; Biological sciences; Immunology; Bioinformatics; Virology

SARS-CoV-2 infection induces imbalanced immune response such as hyperinflammation in patients with severe COVID-19. Here, we studied the immunometabolic regulatory mechanisms for the pathogenesis of COVID-19. We depicted the metabolic landscape of immune cells, especially macrophages, from bronchoal...