MERS, SARS, and Ebola: The Role of Super-Spreaders in Infectious Disease

Super-spreading occurs when a single patient infects a disproportionate number of contacts. The 2015 MERS-CoV, 2003 SARS-CoV, and to a lesser extent 2014–15 Ebola virus outbreaks were driven by super-spreaders. We summarize documented super-spreading in these outbreaks, explore contributing factors,...

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Published in	Cell host & microbe Vol. 18; no. 4; pp. 398 - 401
Main Authors	Wong, Gary, Liu, Wenjun, Liu, Yingxia, Zhou, Boping, Bi, Yuhai, Gao, George F.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 14.10.2015
Subjects	Coronavirus Infections - epidemiology Coronavirus Infections - transmission Coronavirus Infections - virology Disease Outbreaks Disease Transmission, Infectious Ebolavirus - physiology Forum Hemorrhagic Fever, Ebola - epidemiology Hemorrhagic Fever, Ebola - transmission Hemorrhagic Fever, Ebola - virology Humans Middle East Respiratory Syndrome Coronavirus - physiology SARS Virus - physiology Severe Acute Respiratory Syndrome - epidemiology Severe Acute Respiratory Syndrome - transmission Severe Acute Respiratory Syndrome - virology
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Abstract	Super-spreading occurs when a single patient infects a disproportionate number of contacts. The 2015 MERS-CoV, 2003 SARS-CoV, and to a lesser extent 2014–15 Ebola virus outbreaks were driven by super-spreaders. We summarize documented super-spreading in these outbreaks, explore contributing factors, and suggest studies to better understand super-spreading. Super-spreading occurs when a single patient infects a disproportionate number of contacts. The 2015 MERS-CoV, 2003 SARS-CoV, and to a lesser extent 2014–15 Ebola virus outbreaks were driven by super-spreaders. We summarize documented super-spreading in these outbreaks, explore contributing factors, and suggest studies to better understand super-spreading.
AbstractList	Super-spreading occurs when a single patient infects a disproportionate number of contacts. The 2015 MERS-CoV, 2003 SARS-CoV, and to a lesser extent 2014–15 Ebola virus outbreaks were driven by super-spreaders. We summarize documented super-spreading in these outbreaks, explore contributing factors, and suggest studies to better understand super-spreading. Super-spreading occurs when a single patient infects a disproportionate number of contacts. The 2015 MERS-CoV, 2003 SARS-CoV, and to a lesser extent 2014–15 Ebola virus outbreaks were driven by super-spreaders. We summarize documented super-spreading in these outbreaks, explore contributing factors, and suggest studies to better understand super-spreading. Super-spreading occurs when a single patient infects a disproportionate number of contacts. The 2015 MERS-CoV, 2003 SARS-CoV, and to a lesser extent 2014-15 Ebola virus outbreaks were driven by super-spreaders. We summarize documented super-spreading in these outbreaks, explore contributing factors, and suggest studies to better understand super-spreading.
Author	Zhou, Boping Wong, Gary Liu, Wenjun Liu, Yingxia Bi, Yuhai Gao, George F.
Author_xml	– sequence: 1 givenname: Gary surname: Wong fullname: Wong, Gary organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 2 givenname: Wenjun surname: Liu fullname: Liu, Wenjun organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 3 givenname: Yingxia surname: Liu fullname: Liu, Yingxia organization: Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen 518112, China – sequence: 4 givenname: Boping surname: Zhou fullname: Zhou, Boping organization: Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen 518112, China – sequence: 5 givenname: Yuhai surname: Bi fullname: Bi, Yuhai email: beeyh@im.ac.cn organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 6 givenname: George F. surname: Gao fullname: Gao, George F. email: gaof@im.ac.cn organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
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Cites_doi	10.1371/journal.pmed.0030149 10.1056/NEJMoa1404505 10.1371/journal.ppat.1004250 10.3201/eid1906.130192 10.1016/j.virol.2004.09.030 10.1093/oxfordjournals.aje.a009588 10.2807/1560-7917.ES2015.20.25.21163 10.1128/JVI.02836-14 10.1126/science.1259657 10.1126/science.1086478 10.1016/S0140-6736(15)60859-5 10.1056/NEJM199507273330404
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References	Cowling, Park, Fang, Wu, Leung, Wu (bib3) 2015; 20 Paunio, Peltola, Valle, Davidkin, Virtanen, Heinonen (bib9) 1998; 148 Baize, Pannetier, Oestereich, Rieger, Koivogui, Magassouba, Soropogui, Sow, Keïta, De Clerck (bib1) 2014; 371 Lawler, Endy, Hensley, Garrison, Fritz, Lesar, Baric, Kulesh, Norwood, Wasieloski (bib7) 2006; 3 Gire, Goba, Andersen, Sealfon, Park, Kanneh, Jalloh, Momoh, Fullah, Dudas (bib5) 2014; 345 Kline, Hedemark, Davies (bib6) 1995; 333 Su, Wong, Liu, Gao, Li, Bi (bib12) 2015; 385 . Riley, Fraser, Donnelly, Ghani, Abu-Raddad, Hedley, Leung, Ho, Lam, Thach (bib11) 2003; 300 WHO (2015b). Sierra Leone: a traditional healer and a funeral. Braden, Dowell, Jernigan, Hughes (bib2) 2013; 19 Wong, Qiu, Richardson, Cutts, Collignon, Gren, Aviles, Embury-Hyatt, Kobinger (bib15) 2015; 89 McAuliffe, Vogel, Roberts, Fahle, Fischer, Shieh, Butler, Zaki, St Claire, Murphy, Subbarao (bib8) 2004; 330 Promedmail.org (2015). MERS-COV (97): South Korea, Saudi Arabia. International Society for Infectious Diseases. Falzarano, de Wit, Feldmann, Rasmussen, Okumura, Peng, Thomas, van Doremalen, Haddock, Nagy (bib4) 2014; 10 WHO (2015a). Middle East respiratory syndrome coronavirus (MERS-CoV) – Republic of Korea. Disease Outbreak News. 24 May 2015. Braden (10.1016/j.chom.2015.09.013_bib2) 2013; 19 Wong (10.1016/j.chom.2015.09.013_bib15) 2015; 89 Gire (10.1016/j.chom.2015.09.013_bib5) 2014; 345 Cowling (10.1016/j.chom.2015.09.013_bib3) 2015; 20 Falzarano (10.1016/j.chom.2015.09.013_bib4) 2014; 10 Lawler (10.1016/j.chom.2015.09.013_bib7) 2006; 3 Kline (10.1016/j.chom.2015.09.013_bib6) 1995; 333 Su (10.1016/j.chom.2015.09.013_bib12) 2015; 385 Riley (10.1016/j.chom.2015.09.013_bib11) 2003; 300 10.1016/j.chom.2015.09.013_bib13 10.1016/j.chom.2015.09.013_bib14 Baize (10.1016/j.chom.2015.09.013_bib1) 2014; 371 10.1016/j.chom.2015.09.013_bib10 McAuliffe (10.1016/j.chom.2015.09.013_bib8) 2004; 330 Paunio (10.1016/j.chom.2015.09.013_bib9) 1998; 148
References_xml	– volume: 20 start-page: 7 year: 2015 end-page: 13 ident: bib3 article-title: Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015 publication-title: Euro Surveill. – volume: 10 start-page: e1004250 year: 2014 ident: bib4 article-title: Infection with MERS-CoV causes lethal pneumonia in the common marmoset publication-title: PLoS Pathog. – reference: WHO (2015a). Middle East respiratory syndrome coronavirus (MERS-CoV) – Republic of Korea. Disease Outbreak News. 24 May 2015. – volume: 89 start-page: 1314 year: 2015 end-page: 1323 ident: bib15 article-title: Ebola virus transmission in guinea pigs publication-title: J. Virol. – volume: 300 start-page: 1961 year: 2003 end-page: 1966 ident: bib11 article-title: Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions publication-title: Science – reference: . – volume: 148 start-page: 1103 year: 1998 end-page: 1110 ident: bib9 article-title: Explosive school-based measles outbreak: intense exposure may have resulted in high risk, even among revaccinees publication-title: Am. J. Epidemiol. – reference: Promedmail.org (2015). MERS-COV (97): South Korea, Saudi Arabia. International Society for Infectious Diseases. – volume: 333 start-page: 222 year: 1995 end-page: 227 ident: bib6 article-title: Outbreak of tuberculosis among regular patrons of a neighborhood bar publication-title: N. Engl. J. Med. – volume: 371 start-page: 1418 year: 2014 end-page: 1425 ident: bib1 article-title: Emergence of Zaire Ebola virus disease in Guinea publication-title: N. Engl. J. Med. – volume: 19 start-page: 864 year: 2013 end-page: 869 ident: bib2 article-title: Progress in global surveillance and response capacity 10 years after severe acute respiratory syndrome publication-title: Emerg. Infect. Dis. – volume: 345 start-page: 1369 year: 2014 end-page: 1372 ident: bib5 article-title: Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak publication-title: Science – volume: 385 start-page: 2349 year: 2015 end-page: 2350 ident: bib12 article-title: MERS in South Korea and China: a potential outbreak threat? publication-title: Lancet – volume: 3 start-page: e149 year: 2006 ident: bib7 article-title: Cynomolgus macaque as an animal model for severe acute respiratory syndrome publication-title: PLoS Med. – volume: 330 start-page: 8 year: 2004 end-page: 15 ident: bib8 article-title: Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys publication-title: Virology – reference: WHO (2015b). Sierra Leone: a traditional healer and a funeral. – volume: 3 start-page: e149 year: 2006 ident: 10.1016/j.chom.2015.09.013_bib7 article-title: Cynomolgus macaque as an animal model for severe acute respiratory syndrome publication-title: PLoS Med. doi: 10.1371/journal.pmed.0030149 – volume: 371 start-page: 1418 year: 2014 ident: 10.1016/j.chom.2015.09.013_bib1 article-title: Emergence of Zaire Ebola virus disease in Guinea publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1404505 – volume: 10 start-page: e1004250 year: 2014 ident: 10.1016/j.chom.2015.09.013_bib4 article-title: Infection with MERS-CoV causes lethal pneumonia in the common marmoset publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1004250 – volume: 19 start-page: 864 year: 2013 ident: 10.1016/j.chom.2015.09.013_bib2 article-title: Progress in global surveillance and response capacity 10 years after severe acute respiratory syndrome publication-title: Emerg. Infect. Dis. doi: 10.3201/eid1906.130192 – ident: 10.1016/j.chom.2015.09.013_bib10 – volume: 330 start-page: 8 year: 2004 ident: 10.1016/j.chom.2015.09.013_bib8 article-title: Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys publication-title: Virology doi: 10.1016/j.virol.2004.09.030 – ident: 10.1016/j.chom.2015.09.013_bib14 – volume: 148 start-page: 1103 year: 1998 ident: 10.1016/j.chom.2015.09.013_bib9 article-title: Explosive school-based measles outbreak: intense exposure may have resulted in high risk, even among revaccinees publication-title: Am. J. Epidemiol. doi: 10.1093/oxfordjournals.aje.a009588 – ident: 10.1016/j.chom.2015.09.013_bib13 – volume: 20 start-page: 7 year: 2015 ident: 10.1016/j.chom.2015.09.013_bib3 article-title: Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015 publication-title: Euro Surveill. doi: 10.2807/1560-7917.ES2015.20.25.21163 – volume: 89 start-page: 1314 year: 2015 ident: 10.1016/j.chom.2015.09.013_bib15 article-title: Ebola virus transmission in guinea pigs publication-title: J. Virol. doi: 10.1128/JVI.02836-14 – volume: 345 start-page: 1369 year: 2014 ident: 10.1016/j.chom.2015.09.013_bib5 article-title: Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak publication-title: Science doi: 10.1126/science.1259657 – volume: 300 start-page: 1961 year: 2003 ident: 10.1016/j.chom.2015.09.013_bib11 article-title: Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions publication-title: Science doi: 10.1126/science.1086478 – volume: 385 start-page: 2349 year: 2015 ident: 10.1016/j.chom.2015.09.013_bib12 article-title: MERS in South Korea and China: a potential outbreak threat? publication-title: Lancet doi: 10.1016/S0140-6736(15)60859-5 – volume: 333 start-page: 222 year: 1995 ident: 10.1016/j.chom.2015.09.013_bib6 article-title: Outbreak of tuberculosis among regular patrons of a neighborhood bar publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199507273330404
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Snippet	Super-spreading occurs when a single patient infects a disproportionate number of contacts. The 2015 MERS-CoV, 2003 SARS-CoV, and to a lesser extent 2014–15... Super-spreading occurs when a single patient infects a disproportionate number of contacts. The 2015 MERS-CoV, 2003 SARS-CoV, and to a lesser extent 2014-15...
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SubjectTerms	Coronavirus Infections - epidemiology Coronavirus Infections - transmission Coronavirus Infections - virology Disease Outbreaks Disease Transmission, Infectious Ebolavirus - physiology Forum Hemorrhagic Fever, Ebola - epidemiology Hemorrhagic Fever, Ebola - transmission Hemorrhagic Fever, Ebola - virology Humans Middle East Respiratory Syndrome Coronavirus - physiology SARS Virus - physiology Severe Acute Respiratory Syndrome - epidemiology Severe Acute Respiratory Syndrome - transmission Severe Acute Respiratory Syndrome - virology
Title	MERS, SARS, and Ebola: The Role of Super-Spreaders in Infectious Disease
URI	https://dx.doi.org/10.1016/j.chom.2015.09.013 https://www.ncbi.nlm.nih.gov/pubmed/26468744 https://www.proquest.com/docview/1722926343 https://pubmed.ncbi.nlm.nih.gov/PMC7128246
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