RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA)

• Published in: The Journal of biological chemistry Vol. 283; no. 43; pp. 29037 - 29044
• Main Authors: Fan, Wei, Luo, Jianyuan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.10.2008; American Society for Biochemistry and Molecular Biology
• Subjects: Cell Nucleus - metabolism; Cell Survival; Chromatin - metabolism; Cytoplasm - metabolism; DNA Damage; DNA Repair; DNA: , Repair, Recombination, and Chromosome Dynamics; Dose-Response Relationship, Radiation; HeLa Cells; Humans; Models, Biological; Nucleotides - metabolism; RecQ Helicases - metabolism; RecQ Helicases - physiology; Subcellular Fractions - metabolism; Ultraviolet Rays; Xeroderma Pigmentosum Group A Protein - metabolism

Mutations in the RECQL4 helicase gene have been linked to Rothmund-Thomson syndrome, which is characterized by genome instability, cancer susceptibility, and premature aging. To better define the cellular function of the RecQ4 protein, we investigated the subcellular localization of RecQ4 upon treat...