TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1

• Published in: iScience Vol. 19; pp. 177 - 190
• Main Authors: Kang, Hyun Je, Park, Hyun, Yoo, Eun Jin, Lee, Jun Ho, Choi, Soo Youn, Lee-Kwon, Whaseon, Lee, Kyoo-young, Hur, Jin-Hoe, Seo, Jeong Kon, Ra, Jae Sun, Lee, Eun-A., Myung, Kyungjae, Kwon, Hyug Moo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.09.2019; Elsevier
• Subjects: Biochemistry; Biological Sciences; Cell Biology; Molecular Biology; Biological Sciences; Biochemistry; Molecular Biology; Cell Biology

Polyubiquitination of proliferating cell nuclear antigen (PCNA) regulates the error-free template-switching mechanism for the bypass of DNA lesions during DNA replication. PCNA polyubiquitination is critical for the maintenance of genomic integrity; however, the underlying mechanism is poorly unders...