Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction

• Published in: Journal of hepatology Vol. 75; no. Suppl 1; pp. S49 - S66
• Main Authors: Engelmann, Cornelius, Clària, Joan, Szabo, Gyongyi, Bosch, Jaume, Bernardi, Mauro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2021
• Subjects: ACLF; Acute-on-chronic liver failure; Acute-On-Chronic Liver Failure - diagnosis; Acute-On-Chronic Liver Failure - etiology; Ascites; Cirrhosis; DAMP; Hepatic encephalopathy; Humans; Inflammation; Liver Circulation; Liver Cirrhosis - complications; Liver Cirrhosis - immunology; Liver Cirrhosis - metabolism; Liver Cirrhosis - physiopathology; Organ failure; Oxidative Stress; PAMP; Prognosis; Tissue injury; Variceal bleeding; Organ failure; Cirrhosis; PAMP; ACLF; Tissue injury; Variceal bleeding; Acute-on-chronic liver failure; Ascites; Hepatic encephalopathy; DAMP

Patients with acutely decompensated cirrhosis have a dismal prognosis and frequently progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic organ failure(s). The pathomechanisms involved in decompensation and disease progression are still not well understood,...