Maternal fiber deprivation alters microbiota in offspring, resulting in low-grade inflammation and predisposition to obesity

• Published in: Cell host & microbe Vol. 31; no. 1; pp. 45 - 57.e7
• Main Authors: Zou, Jun, Ngo, Vu L., Wang, Yanling, Wang, Yadong, Gewirtz, Andrew T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.01.2023
• Subjects: Diet, High-Fat - adverse effects; Dysbiosis; Female; gut microbiota; Humans; Inflammation - microbiology; inulin; Lactation; maternal diets; Microbiota; obesity; Obesity - microbiology; offspring; inulin; offspring; maternal diets; obesity; gut microbiota

Diet, especially fiber content, plays an important role in sustaining a healthy gut microbiota, which promotes intestinal and metabolic health. Another major determinant of microbiota composition is the specific microbes that are acquired early in life, especially maternally. Consequently, we hypoth...