Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene

• Published in: Cell host & microbe Vol. 24; no. 4; pp. 569 - 578.e4
• Main Authors: Wu, Nicholas C., Yamayoshi, Seiya, Ito, Mutsumi, Uraki, Ryuta, Kawaoka, Yoshihiro, Wilson, Ian A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.10.2018
• Subjects: Animals; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - genetics; Antibodies, Neutralizing - immunology; Antibodies, Viral - chemistry; Antibodies, Viral - genetics; Antibodies, Viral - immunology; Binding Sites, Antibody - immunology; broadly neutralizing antibody; CHO Cells; Cricetulus; Epitopes - immunology; hemagglutinin; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Humans; immune response; influenza; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - immunology; Influenza Vaccines - immunology; Influenza, Human - virology; Reading Frames - immunology; Sequence Analysis, Protein; Sf9 Cells; X-ray crystallography; influenza; X-ray crystallography; broadly neutralizing antibody; immune response; hemagglutinin

Discovery and characterization of broadly neutralizing antibodies (bnAbs) to the influenza hemagglutinin (HA) stem have provided insights for the development of a universal flu vaccine. Identification of signature features common to bnAbs from different individuals will be key to guiding immunogen d...