Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression

• Published in: Cell host & microbe Vol. 18; no. 1; pp. 61 - 74
• Main Authors: Lubick, Kirk J., Robertson, Shelly J., McNally, Kristin L., Freedman, Brett A., Rasmussen, Angela L., Taylor, R. Travis, Walts, Avram D., Tsuruda, Seitaro, Sakai, Mizuki, Ishizuka, Mariko, Boer, Elena F., Foster, Erin C., Chiramel, Abhilash I., Addison, Conrad B., Green, Richard, Kastner, Daniel L., Katze, Michael G., Holland, Steven M., Forlino, Antonella, Freeman, Alexandra F., Boehm, Manfred, Yoshii, Kentaro, Best, Sonja M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.07.2015
• Subjects: Dipeptidases - metabolism; Encephalitis Viruses, Tick-Borne - immunology; Fibroblasts - immunology; Host-Pathogen Interactions; Humans; Interferon Type I - metabolism; Protein Binding; Receptor, Interferon alpha-beta - metabolism; Signal Transduction; Viral Nonstructural Proteins - metabolism; West Nile virus - immunology

Type I interferon (IFN-α/β or IFN-I) signals through two receptor subunits, IFNAR1 and IFNAR2, to orchestrate sterile and infectious immunity. Cellular pathways that regulate IFNAR1 are often targeted by viruses to suppress the antiviral effects of IFN-I. Here we report that encephalitic flaviviruse...