Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization

• Published in: Cell host & microbe Vol. 29; no. 5; pp. 747 - 751.e4
• Main Authors: Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Wang, Maple, Yu, Jian, Cerutti, Gabriele, Liu, Lihong, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.05.2021
• Subjects: Adult; Aged; Animals; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; antibody; Brief Report; Chlorocebus aethiops; convalescent plasma; COVID-19 Vaccines - immunology; Female; HEK293 Cells; Humans; Male; Middle Aged; mutation; neutralization; Neutralization Tests; NTD; P.1; RBD; SARS-CoV-2; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; vaccine; variant; Vero Cells; mutation; SARS-CoV-2; P.1; vaccine; antibody; RBD; neutralization; variant; convalescent plasma; NTD

The emergence of SARS-CoV-2 variants has raised concerns about altered sensitivity to antibody-mediated immunity. The relative resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to antibody neutralization has been recently investigated. We report that another emergent variant from Brazil, P.1, is...