Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy

• Published in: Acta pharmaceutica Sinica. B Vol. 12; no. 2; pp. 924 - 938
• Main Authors: Cheng, Xiaobei, Yu, Pei, Zhou, Xiang, Zhu, Jiale, Han, Yubao, Zhang, Chao, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2022; Elsevier
• Subjects: Chemotherapy; Combination therapy; Drug delivery; Liposomes; Nano therapy; Neutrophil infiltration; Original; Pathogen-mediated tumor targeting; Resiquimod; Chemotherapy; Resiquimod; Pathogen-mediated tumor targeting; Drug delivery; Nano therapy; Neutrophil infiltration; Liposomes; Combination therapy

Although multifarious tumor-targeting modifications of nanoparticulate systems have been attempted in joint efforts by our predecessors, it remains challenging for nanomedicine to traverse physiological barriers involving blood vessels, tissues, and cell barriers to thereafter demonstrate excellent...