Evidence of premature lymphocyte aging in people with low anti-spike antibody levels after BNT162b2 vaccination

• Published in: iScience Vol. 25; no. 10; p. 105209
• Main Authors: Huang, Yapei, Shin, Juliana E., Xu, Alexander M., Yao, Changfu, Joung, Sandy, Wu, Min, Zhang, Ruan, Shin, Bongha, Foley, Joslyn, Mahov, Simeon B., Modes, Matthew E., Ebinger, Joseph E., Driver, Matthew, Braun, Jonathan G., Jefferies, Caroline A., Parimon, Tanyalak, Hayes, Chelsea, Sobhani, Kimia, Merchant, Akil, Gharib, Sina A., Jordan, Stanley C., Cheng, Susan, Goodridge, Helen S., Chen, Peter
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.10.2022; The Author(s); Elsevier
• Subjects: Health sciences; Immunology; Microbiology; Transcriptomics; Health sciences; Immunology; Microbiology; Transcriptomics

SARS-CoV-2 vaccines have unquestionably blunted the overall impact of the COVID-19 pandemic, but host factors such as age, sex, obesity, and other co-morbidities can affect vaccine efficacy. We identified individuals in a relatively healthy population of healthcare workers (CORALE study cohort) who...