Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV?

• Published in: Clinical infectious diseases Vol. 54; no. 7; pp. 984 - 994
• Main Authors: Justice, Amy C., Freiberg, Matthew S., Tracy, Russ, Kuller, Lew, Tate, Janet P., Goetz, Matthew Bidwell, Fiellin, David A., Vanasse, Gary J., Butt, Adeel A., Rodriguez-Barradas, Maria C., Gibert, Cynthia, Oursler, Kris Ann, Deeks, Steven G., Bryant, Kendall
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.2012
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Antiretrovirals; Biological and medical sciences; Biological markers; Biomarkers; Biomarkers - blood; Coagulation; Cohort studies; Female; Fibrin Fibrinogen Degradation Products - analysis; Hemoglobin; Hepatitis C virus; HIV; HIV 1; HIV infections; HIV Infections - diagnosis; HIV Infections - mortality; HIV Infections - pathology; HIV-1 - immunology; HIV-1 - pathogenicity; HIV/AIDS; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infections; Infectious diseases; Inflammation; Interleukin-6 - blood; Lipopolysaccharide Receptors - blood; Male; Medical sciences; Middle Aged; Mortality; Prognosis; Ribonucleic acid; RNA; Survival Analysis; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Immunopathology; Prognosis; Monocyte; Mortality; Coagulation; Retroviridae; AIDS; Inflammation; Immune deficiency; Lentivirus; Infection; Virus; Viral disease; Human immunodeficiency virus

Background. When added to age, CD4 count and human immunodeficiency virus type 1 (HIV-1) RNA alone (Restricted Index), hemoglobin, FIB-4 Index, hepatitis C virus (HCV), and estimated glomerular filtration rate improve prediction of mortality. Weighted and combined, these 7 routine clinical variables...