The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation - Hooftman, Alexander; Angiari, Stefano; Hester, Svenja; Corcoran, Sarah E.; Runtsch, Marah C.; Ling, Chris; Ruzek, Melanie C.; Slivka, Peter F.; McGettrick, Anne F.; Banahan, Kathy; Hughes, Mark M.; Irvine, Alan D.; et al. (Cell metabolism, 2020)
Keywords: Animals; cysteine modification; IL-1β; Immunologic Factors - pharmacology; immunometabolism; inflammasome; Inflammasomes - antagonists & inhibitors; Inflammasomes - metabolism; itaconate; macrophage; metabolite; Mice; Mice, Inbred C57BL; Mice, Knockout; NEK7; NLR Family, Pyrin Domain-Containing 3 Protein - deficiency; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3; pyroptosis; Short; Succinates - pharmacology; pyroptosis; itaconate; metabolite; immunometabolism; inflammasome; NEK7; cysteine modification; NLRP3; macrophage; IL-1β