PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease

• Published in: Cell metabolism Vol. 33; no. 6; pp. 1187 - 1204.e9
• Main Authors: Moreno-Fernandez, Maria E., Giles, Daniel A., Oates, Jarren R., Chan, Calvin C., Damen, Michelle S.M.A., Doll, Jessica R., Stankiewicz, Traci E., Chen, Xiaoting, Chetal, Kashish, Karns, Rebekah, Weirauch, Matthew T., Romick-Rosendale, Lindsey, Xanthakos, Stavra A., Sheridan, Rachel, Szabo, Sara, Shah, Amy S., Helmrath, Michael A., Inge, Thomas H., Deshmukh, Hitesh, Salomonis, Nathan, Divanovic, Senad
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021
• Subjects: Animals; Carrier Proteins - immunology; Cell Line; cellular metabolism; CXCR3; Female; glycolysis; Humans; IFNγ; liver; Male; Membrane Proteins - immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; NAFLD; Non-alcoholic Fatty Liver Disease - immunology; obesity; PKM; Pyruvate Kinase - immunology; Receptors, CXCR3 - immunology; T cell; Th17 Cells - cytology; Th17 Cells - immunology; Thyroid Hormone-Binding Proteins; Thyroid Hormones - immunology; TNF; IFNγ; NAFLD; PKM; liver; CXCR3; T cell; cellular metabolism; glycolysis; TNF; obesity

Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD) pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic Th17 cells, however, remain unknown. Here, we uncover and characterize a distinct population of inflammatory hepatic CXCR3+T...