Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation

• Published in: Cell host & microbe Vol. 29; no. 11; pp. 1649 - 1662.e7
• Main Authors: Chipashvili, Otari, Utter, Daniel R., Bedree, Joseph K., Ma, Yansong, Schulte, Fabian, Mascarin, Gabrielle, Alayyoubi, Yasmin, Chouhan, Deepak, Hardt, Markus, Bidlack, Felicitas, Hasturk, Hatice, He, Xuesong, McLean, Jeffrey S., Bor, Batbileg
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.11.2021
• Subjects: Actinobacteria; Actinobacteria - genetics; Actinobacteria - isolation & purification; Actinobacteria - pathogenicity; Actinobacteria - physiology; Actinomyces; Actinomyces - genetics; Actinomyces - isolation & purification; Actinomyces - pathogenicity; Actinomyces - physiology; Alveolar Bone Loss - microbiology; Alveolar Bone Loss - prevention & control; Animals; Bacteria - classification; Bacteria - isolation & purification; Bacteria - pathogenicity; Bacterial Infections - microbiology; Bacterial Infections - prevention & control; Bacterial Physiological Phenomena; bacterial symbiosis; candidate phyla radiation; Collagen - metabolism; Dental Plaque - microbiology; Down-Regulation; Genes, Bacterial; Gingivitis - microbiology; Gingivitis - prevention & control; human microbiome; human oral microbiome; Humans; inflammatory disease; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microbiota; N-Acetylneuraminic Acid - metabolism; periodontitis; Periodontitis - microbiology; Periodontitis - prevention & control; Propionibacteriaceae - genetics; Propionibacteriaceae - isolation & purification; Propionibacteriaceae - pathogenicity; Propionibacteriaceae - physiology; Saccharibacteria; Symbiosis; TM7; Virulence; human microbiome; periodontitis; human oral microbiome; Actinomyces; candidate phyla radiation; inflammatory disease; Actinobacteria; Saccharibacteria; bacterial symbiosis; TM7

Saccharibacteria (TM7) are obligate epibionts living on the surface of their host bacteria and are strongly correlated with dysbiotic microbiomes during periodontitis and other inflammatory diseases, suggesting they are putative pathogens. However, due to the recalcitrance of TM7 cultivation, causal...