Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

• Published in: Cell metabolism Vol. 30; no. 2; pp. 352 - 363.e8
• Main Authors: Puleston, Daniel J., Buck, Michael D., Klein Geltink, Ramon I., Kyle, Ryan L., Caputa, George, O’Sullivan, David, Cameron, Alanna M., Castoldi, Angela, Musa, Yaarub, Kabat, Agnieszka M., Zhang, Ying, Flachsmann, Lea J., Field, Cameron S., Patterson, Annette E., Scherer, Stefanie, Alfei, Francesca, Baixauli, Francesc, Austin, S. Kyle, Kelly, Beth, Matsushita, Mai, Curtis, Jonathan D., Grzes, Katarzyna M., Villa, Matteo, Corrado, Mauro, Sanin, David E., Qiu, Jing, Pällman, Nora, Paz, Katelyn, Maccari, Maria Elena, Blazar, Bruce R., Mittler, Gerhard, Buescher, Joerg M., Zehn, Dietmar, Rospert, Sabine, Pearce, Edward J., Balabanov, Stefan, Pearce, Erika L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.08.2019; Cell Press
• Subjects: Animals; Cells, Cultured; deoxyhypusine hydroxylase; deoxyhypusine synthase; eIF5A; Eukaryotic Translation Initiation Factor 5A; hypusination; immunometabolism; Macrophage Activation; Macrophages - metabolism; metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria - metabolism; Peptide Initiation Factors - metabolism; polyamines; Polyamines - metabolism; Proteomics; RNA-Binding Proteins - metabolism; hypusination; immunometabolism; deoxyhypusine hydroxylase; metabolism; macrophage activation; deoxyhypusine synthase; polyamines; eIF5A

How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We show here that hypusinated eIF5A (eIF5AH) promotes the effici...